From Martin Scorsese's 1988 film, The Last Temptation of Christ.
Cinematographers have been inspired by classical painting for many years, but this is a prime example of just how influential those classic images can be. This shot is a direct descendant of a 16th Century painting by Hieronymus Bosch, titled Christ Carrying the Cross.
What's most impressive to me, as far as how the painting was replicated for film, is how they managed to fill the shot with actors whose faces are almost as varied and animated as the faces in the painting. Also, you can tell the cinematographer (Michael Ballhaus) used a long focal lens to flatten the depth of the image, simulating the crowded and 2-dimensional layout of the painting.